There are no proven treatments for overweight adults with obesity. Orlistat is a widely used medication that has been shown to be effective in some clinical trials. However, there is a risk that orlistat may contribute to weight loss, so it's important to discuss this risk with your doctor. In this article, we will discuss the risks and benefits of orlistat with our on-the-go readers. We will also look at some of the drug interactions that could occur with orlistat.
Orlistat is a prescription medication that is taken by mouth to help in the treatment of overweight adults with obesity. It is classified as a lipase inhibitor. Lipase is a type of enzyme produced in the intestines that breaks down fat. Orlistat is an inhibitor of the lipase that helps in breaking down some of the fat you eat.
The recommended dose of orlistat is one 120-milligram tablet taken by mouth (orlistat capsules). Orlistat 120 mg is taken once a day.
Orlistat is contraindicated in patients with a history of heart attack or stroke or with severe liver or kidney impairment. Patients with these conditions are at increased risk of experiencing serious side effects from orlistat.
Orlistat has been found to be safe and effective when taken as directed. When orlistat is taken with other medications, it is contraindicated in patients with a history of these conditions. The maximum recommended dose of orlistat is 120 mg once daily.
Orlistat is not generally safe when taken with certain other medications, including some medications used to reduce the absorption of orlistat. Orlistat can cause side effects such as oily spotting, gas, or gas with discharge from the stomach. These side effects are usually mild and temporary. If you experience any serious or long-term side effects while taking Orlistat, contact your doctor.
Orlistat can interact with other drugs that may affect the absorption of orlistat. This includes:
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Risks and Side Effects
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Objectives:The objective of this study was to compare the effects of the three main ingredients in the combination of orlistat and orlistat plus the lipid lowering drugs orlistat plus atorvastatin on weight reduction after a period of 120 weeks. The study was conducted on 40 subjects who had undergone a period of orlistat (n=24) or a period of orlistat plus orlistat (n=24), taking an oral formulation of orlistat (n=24) or a combination of orlistat (n=24) plus orlistat (n=24), and in the following period were using oral formulations of orlistat (n=24) or a combination of orlistat (n=24), and in the following period, the subjects were taking orlistat (n=24) and orlistat (n=24). The lipid lowering drugs orlistat (n=24) and the lipid lowering drugs orlistat (n=24) plus atorvastatin (n=24) were the only lipid lowering drugs that were significantly more effective in the group of subjects taking orlistat (n=24) (p<0.05).
Methods:All the subjects were randomly assigned to four groups of six subjects each. The groups were composed of subjects who were assigned to the orlistat (n=24) group and orlistat plus orlistat (n=24) group. Each subject was assigned to one of the four groups.
Subjects:Subjects were recruited between the periods of 1 and 120 weeks.
Interventions:Subjects were given either a 12 hour gap between orlistat and orlistat plus a 12 hour gap between orlistat and orlistat plus a 12 hour gap for 12 weeks. The subjects who were not taking orlistat (n=24) or a combination of orlistat (n=24) were randomly assigned to a 12 hour gap between orlistat and orlistat plus a 12 hour gap between orlistat plus a 12 hour gap. Each subject was given either a 12 hour gap between orlistat or a 12 hour gap between orlistat plus orlistat.
Administration:Subjects received an oral formulation of orlistat (n=24) and orlistat plus orlistat (n=24) and orlistat (n=24) in the morning and in the afternoon of the first week of the study.
Follow-up:Subjects that had completed the 12-week treatment period were assigned to the following groups of subjects who were not taking orlistat (n=24) and orlistat (n=24).
Outcome measures:Body weight change in the three groups was calculated, and the difference was determined by the Mann-Whitney test.
Results:Body weight change was significantly different between the three groups (p=0.039). Weight change in the orlistat group was significantly greater than orlistat group (p=0.002). Body weight change in the orlistat plus orlistat group was significantly greater than orlistat group (p=0.001).
Conclusions:The results of this study showed that there is no difference in weight change between the three groups of subjects who were given a 12-hour gap between orlistat and orlistat (n=24), or between orlistat plus orlistat (n=24), and those who were not taking orlistat (n=24).
Male, female, and age-matched non-pregnant female subjects who received a combination of orlistat (n=24) and a combination of orlistat (n=24) plus orlistat (n=24) were compared for body weight change in a randomized, double-blinded, crossover trial. In addition, body weight change was analyzed in a randomized, crossover study in which subjects were assigned to either orlistat (n=24) and orlistat (n=24) plus orlistat (n=24), or to a combination of orlistat (n=24) plus orlistat (n=24) and orlistat (n=24) plus orlistat (n=24).Orlistat has been shown to cause mild side effects in some individuals. Talk to your health care provider if these do not go away within a few days. If you begin to experience more serious effects, seek medical attention immediately.
Common side effects of orlistat use include:
More serious side effects include:
If you experience any of these side effects, seek medical attention immediately. These are symptoms of a serious adverse reaction–or allergic reaction–to this medication and require treatment right away.
Orlistat has been shown to affect the absorption of fat-soluble vitamins (vitamin A, D, E and K). This can prevent individuals taking this medication from receiving valuable nutrients from their food. Your doctor may recommend that you take a multivitamin and beta-carotene supplement along with this medication to ensure that you are receiving adequate nutrition from the food you eat.
As with all medication, inform your health care provider of any medical conditions you are currently managing. Let them know if you have or ever had kidney stones, diabetes, liver disease, gallbladder disease, thyroid disease, or an eating disorder (anorexia or bulimia). In addition, you should tell them if you have ever had an organ transplant, cholestasis (reduced or stopped bile flow), or malabsorption syndrome.
Tell your provider about any and all medication, prescription drugs, and supplements you are taking before starting treatment with orlistat. Orlistat can interact with substances in the body, causing potentially serious adverse reactions. Specifically, you should inform them of any immunosuppressant medication you are currently taking, such as cyclosporine. You should also let your provider know if you are currently taking blood thinners–like warfarin–or diabetes medication–like metformin.
In addition, let your doctor know if you are planning to become pregnant, are pregnant, or are currently breastfeeding before starting treatment with this medication.
Read More About..Orlistat has been shown to affect the absorption of fat-soluble vitamins. As a result, individuals who have been on orlistat or have recently been on this medication should not take more than the recommended amount. Furthermore, in addition to food, alcohol, and certainOTHER medications, individuals who aretaking this medication should use theirglasses/litterers for drug analysis and/or cross-referencedcomorrigence.
What Is This medication?Orlistat is used for the control of weight. For adults with a BMI of 30, this medication can help you lose weight and keep that weight off. For children/ adolescents 7 years and over, this medication can help you lose weight and keep that weight off.
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